by Contents
Movie
| Year | Movie | Role |
| 2000 | Girlfight | Diana Guzman |
| 2001 | The Fast and the Furious | Letty Ortiz |
| 2001 | 3 A.M. | Salgado |
| 2002 | Resident Evil | Rain Ocampo |
| 2002 | Blue Crush | Eden |
| 2003 | S.W.A.T. | Officer Chris Sanchez |
| 2004 | Control | Teresa |
| 2005 | BloodRayne | Katarin |
| 2006 | The Breed | Nicki |
| 2007 | Battle in Seattle | Lou |
| 2008 | Gardens of the Night | Lucy |
| 2008 | Adventures in Voice Acting | Herself |
| 2009 | Fast & Furious | Letty Ortiz |
| 2009 | Los Bandoleros | Letty Ortiz |
| 2009 | Avatar | Captain Trudy Chacon |
| 2010 | Machete | Luz / Shé |
| 2010 | Trópico de Sangre | Minerva Mirabal |
| 2011 | Battle: Los Angeles | Technical Sergeant Elana Santos |
| 2011 | Fast Five | Letty Ortiz |
| 2012 | Resident Evil: Retribution | Rain Ocampo |
| 2013 | InAPPropriate Comedy | Harriet |
| 2013 | Fast & Furious 6 | Letty Ortiz |
| 2013 | Turbo | Paz (voice) |
| 2013 | Machete Kills | Luz / Shé |
| 2015 | Furious 7 | Letty Ortiz |
| 2016 | The Assignment | Frank Kitchen / Tomboy |
| 2016 | Milton’s Secret | Ms. Ferguson |
| 2017 | Smurfs: The Lost Village | Smurf Storm (voice) |
| 2017 | The Fate of the Furious | Letty Ortiz |
| 2018 | Widows | Linda |
| 2019 | Alita: Battle Angel | Gelda |
| 2020 | She Dies Tomorrow | Sky |
| 2021 | Crisis | Supervisor Garrett |
| 2021 | F9 | Letty Ortiz |
TV Show
| Year | TV Show | Role |
| 2003 | Slavi’s Show | Herself |
| 2005 | Punk’d | Herself |
| 2005–06 | Immortal Grand Prix | Liz Ricarro |
| 2005–06, 2009–10 | Lost | Ana Lucia Cortez |
| 2011 | CollegeHumor Original | Jessica |
| 2012 | Germany’s Next Top Model | Herself |
| 2015 | Running Wild with Bear Grylls | Herself |
| 2015 | Super Into | Herself |
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