by Movie
| Year | Movie | Role |
| TBA | Untitled Nora Fingscheidt project | Ruth Slater |
|---|---|---|
| TBA | Bullet Train | |
| 1987 | Hangmen | Lisa Edwards |
| 1989 | A Fool and His Money | Debby Cosgrove |
| 1989 | Who Shot Patakango? | Devlin Moran |
| 1992 | Love Potion No. 9 | Diane Farrow |
| 1993 | The Vanishing | Diane Shaver |
| 1993 | When the Party’s Over | Amanda |
| 1993 | The Thing Called Love | Linda Lue Linden |
| 1993 | Demolition Man | Lenina Huxley |
| 1993 | Fire on the Amazon | Alyssa Rothman |
| 1993 | Wrestling Ernest Hemingway | Elaine |
| 1994 | Speed | Annie Porter |
| 1994 | Who Do I Gotta Kill? | Lori |
| 1995 | While You Were Sleeping | Lucy Eleanor Moderatz |
| 1995 | The Net | Angela Bennett |
| 1996 | Two If by Sea | Roz |
| 1996 | A Time to Kill | Ellen Roark |
| 1996 | In Love and War | Agnes von Kurowsky |
| 1997 | Speed 2: Cruise Control | Annie Porter |
| 1998 | Hope Floats | Birdee Pruitt |
| 1998 | Making Sandwiches | Melba Club |
| 1998 | Practical Magic | Sally Owens |
| 1998 | The Prince of Egypt | Miriam (voice) |
| 1999 | Forces of Nature | Sarah Lewis |
| 2000 | Gun Shy | Judy Tipp |
| 2000 | 28 Days | Gwen Cummings |
| 2000 | Miss Congeniality | Gracie Hart |
| 2002 | Murder by Numbers | Det. Cassie Mayweather |
| 2002 | Divine Secrets of the Ya-Ya Sisterhood | Siddalee Walker |
| 2002 | Two Weeks Notice | Lucy Kelson |
| 2004 | Crash | Jean Cabot |
| 2005 | Loverboy | Mrs. Harker |
| 2005 | Miss Congeniality 2: Armed and Fabulous | Gracie Hart |
| 2006 | The Lake House | Dr. Kate Forster |
| 2006 | Infamous | Harper Lee |
| 2007 | Premonition | Linda Hanson |
| 2009 | The Proposal | Margaret Tate |
| 2009 | All About Steve | Mary Horowitz |
| 2009 | The Blind Side | Leigh Anne Tuohy |
| 2011 | Extremely Loud & Incredibly Close | Linda Schell |
| 2013 | The Heat | Special Agent Sarah Ashburn |
| 2013 | Gravity | Dr. Ryan Stone |
| 2013 | The Prime Ministers: The Pioneers | Golda Meir (voice) |
| 2015 | Minions | Scarlet Overkill (voice) |
| 2015 | Our Brand Is Crisis | “Calamity” Jane Bodine |
| 2018 | Ocean’s 8 | Debbie Ocean |
| 2018 | Bird Box | Malorie Hayes |
| Year | TV Show | Role |
| 1989 | Bionic Showdown: The Six Million Dollar Man and the Bionic Woman | Kate Mason |
|---|---|---|
| 1989 | Starting from Scratch | Barbara Webster |
| 1989 | The Preppie Murder | Stacy |
| 1990 | Working Girl | Tess McGill |
| 1990 | Lucky Chances | Maria Santangelo |
| 2002−2004 | George Lopez | Accident Amy |
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