by Contents
Movie
| Year | Movie | Role |
| 1993 | Mi Vida Loca | Gata |
| 1994 | Roadracers | Donna |
| 1995 | El Callejón de los Milagros | Alma |
| 1995 | Desperado | Carolina |
| 1995 | Fair Game | Rita |
| 1995 | Four Rooms | TV Dancing Girl |
| 1996 | From Dusk till Dawn | Santanico Pandemonium |
| 1996 | Follow Me Home | Betty |
| 1996 | Fled | Cora |
| 1997 | Fools Rush In | Isabel Fuentes |
| 1997 | Breaking Up | Monica |
| 1997 | Sistole Diastole | Carmelita |
| 1998 | 54 | Anita |
| 1998 | The Velocity of Gary | Mary Carmen |
| 1998 | The Faculty | Nurse Harper |
| 1999 | Dogma | Serendipity |
| 1999 | El Coronel No Tiene Quien Le Escriba | Julia |
| 1999 | Wild Wild West | Rita Escobar |
| 2000 | Timecode | Rose |
| 2000 | Living It Up | Lola |
| 2000 | Chain of Fools | Sergeant Meredith Kolko |
| 2000 | Traffic | Rosario |
| 2001 | Hotel | Charlee Boux |
| 2001 | In the Time of the Butterflies | Minerva Mirabal |
| 2002 | Frida | Frida Kahlo |
| 2003 | Spy Kids 3-D: Game Over | Francesca Giggles |
| 2003 | Once Upon a Time in Mexico | Carolina |
| 2003 | V-Day: Until the Violence Stops | Herself |
| 2004 | After the Sunset | Lola Cirillo |
| 2006 | Ask the Dust | Camilla Lopez |
| 2006 | Bandidas | Sara Sandoval |
| 2006 | Lonely Hearts | Martha Beck |
| 2007 | Across the Universe | Bang Bang Shoot Shoot Nurses |
| 2009 | Cirque du Freak: The Vampire’s Assistant | Madame Truska |
| 2010 | Grown Ups | Roxanne |
| 2011 | Puss in Boots | Kitty Softpaws (voice) |
| 2011 | Americano | Lola |
| 2011 | La chispa de la vida | Luisa |
| 2012 | The Pirates! In an Adventure with Scientists! | Cutlass Liz (voice) |
| 2012 | Savages | Elena |
| 2012 | Here Comes the Boom | Bella Flores |
| 2013 | Grown Ups 2 | Roxanne Chase-Feder |
| 2014 | Muppets Most Wanted | Herself |
| 2014 | Kahlil Gibran’s The Prophet | Kamila (voice) |
| 2014 | Everly | Everly |
| 2014 | Some Kind of Beautiful | Olivia |
| 2015 | Tale of Tales | Queen of Longtrellis |
| 2015 | Septembers of Shiraz | Farnez |
| 2016 | Sausage Party | Theresa Taco (voice) |
| 2017 | Beatriz at Dinner | Beatriz |
| 2017 | How to Be a Latin Lover | Sara |
| 2017 | The Hitman’s Bodyguard | Sonia Kincaid |
| 2018 | The Hummingbird Project | Eva Torres |
| 2019 | Drunk Parents | Nancy |
| 2020 | Like a Boss | Claire Luna |
| 2020 | The Roads Not Taken | Dolores |
| 2021 | Bliss | Isabel |
| 2021 | Eternals | Ajak |
| 2021 | The Hitman’s Wife’s Bodyguard | Sonia Kincaid |
TV Show
| Year | TV Show | Role |
| 1988 | Un Nuevo Amanecer | Fabiola |
| 1989 | Teresa | Teresa |
| 1992 | Dream On | Carmela |
| 1993 | The Sinbad Show | Gloria Contreras |
| 1994 | Roadracers | Donna |
| 1994 | El vuelo del águila | Juana Cata |
| 1997 | The Hunchback | Esmeralda |
| 1997 | Gente Bien | Teresa |
| 1999 | Action | Herself |
| 2001 | In the Time of the Butterflies | Minerva Mirabal |
| 2003 | The Maldonado Miracle | |
| 2003 | Saturday Night Live | Guest host |
| 2006–2010 | Ugly Betty | Sofia Reyes / Nurse in Telenovela |
| 2009–2013 | 30 Rock | Elisa Pedrera |
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