by Contents
Movies
| Year | Movie | Role |
| 2008 | Vigilante | Cassandra |
| 2009 | ICU | Tristan Waters |
| 2013 | About Time | Charlotte |
| 2013 | The Wolf of Wall Street | Naomi Lapaglia |
| 2015 | Z for Zachariah | Ann Burden |
| 2015 | Focus | Jess Barrett |
| 2015 | Suite Française | Celine |
| 2015 | The Big Short | Herself |
| 2016 | Whiskey Tango Foxtrot | Tanya Vanderpoel |
| 2016 | The Legend of Tarzan | Jane Porter |
| 2016 | Suicide Squad | Dr. Harleen Quinzel / Harley Quinn |
| 2017 | Goodbye Christopher Robin | Daphne de Sélincourt |
| 2017 | I, Tonya | Tonya Harding |
| 2018 | Peter Rabbit | Flopsy Rabbit |
| 2018 | Terminal | Annie / Bonnie |
| 2018 | Slaughterhouse Rulez | Audrey |
| 2018 | Mary Queen of Scots | Queen Elizabeth I |
| 2019 | Dreamland | Allison Wells |
| 2019 | Once Upon a Time in Hollywood | Sharon Tate |
| 2019 | Bombshell | Kayla Pospisil |
| 2020 | Birds of Prey | Dr. Harleen Quinzel / Harley Quinn |
| 2020 | Promising Young Woman | N/A |
| 2021 | Peter Rabbit 2: The Runaway | Flopsy Rabbit |
| 2021 | The Suicide Squad | Dr. Harleen Quinzel / Harley Quinn |
| TBA | Untitled David O. Russell film | TBA |
TV Shows
| Year | TV Show | Role |
| 2008 | Review with Myles Barlow | Kelly |
| 2008 | City Homicide | Caitlin Brentford |
| 2008-2011 | Neighbours | Juliet |
| 2009 | The Elephant Princess | Donna Freedman |
| 2009 | Talkin’ ‘Bout Your Generation | Herself |
| 2011-2012 | Pan Am | Laura Cameron |
| 2015 | Neighbours 30th: The Stars Reunite | Herself |
| 2015 | Top Gear | Herself |
| 2016 | Saturday Night Live | Host |
| 2019 | Dollface | Imelda |
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