by Contents
Movie
| Year | Movie | Role |
| 1994 | Camp Nowhere | Gail |
| 1995 | Venus Rising | Young Eve |
| 1999 | P.U.N.K.S. | Samantha Swoboda |
| 1999 | Never Been Kissed | Kirsten Liosis |
| 1999 | Idle Hands | Molly |
| 2000 | Paranoid | Chloe |
| 2003 | The Sleeping Dictionary | Selima |
| 2003 | Honey | Honey Daniels |
| 2005 | Sin City | Nancy Callahan |
| 2005 | Fantastic Four | Sue Storm / Invisible Woman |
| 2005 | Into the Blue | Sam |
| 2007 | The Ten | Liz Anne Blazer |
| 2007 | Knocked Up | Herself |
| 2007 | Fantastic Four: Rise of the Silver Surfer | Sue Storm / Invisible Woman |
| 2007 | Good Luck Chuck | Cam Wexler |
| 2007 | Meet Bill | Lucy |
| 2007 | Awake | Sam Lockwood |
| 2008 | The Eye | Sydney Wells |
| 2008 | The Love Guru | Jane Bullard |
| 2010 | The Killer Inside Me | Joyce Lakeland |
| 2010 | Valentine’s Day | Morley Clarkson |
| 2010 | Machete | Special Agent Sartana Rivera |
| 2010 | Machete | Marissa Rivera |
| 2010 | An Invisible Sign | Mona Gray |
| 2010 | Little Fockers | Andi Garcia[150][151] |
| 2011 | Spy Kids: All the Time in the World | Marissa Wilson |
| 2012 | Martin Scorsese Eats a Cookie | Herself |
| 2013 | A.C.O.D. | Michelle |
| 2013 | Escape from Planet Earth | Lena (voice) |
| 2013 | Machete Kills | Sartana |
| 2014 | Sin City: A Dame to Kill For | Nancy Callahan |
| 2014 | Stretch | Charlie |
| 2014 | Some Kind of Beautiful | Kate |
| 2015 | Barely Lethal | Victoria Knox |
| 2015 | Entourage | Herself |
| 2016 | The Veil | Maggie Price |
| 2016 | Dear Eleanor | Daisy |
| 2016 | Mechanic: Resurrection | Gina |
| 2017 | El Camino Christmas | Beth Flowers |
| 2019 | Killers Anonymous | Jade |
TV Show
| Year | TV Show | Role |
| 1994 | The Secret World of Alex Mack | Jessica |
| 1995–1997 | Flipper | Maya Graham |
| 1996 | ABC Afterschool Special | Christy |
| 1996 | Chicago Hope | Florie Hernandez |
| 1998 | Brooklyn South | Melissa Hauer |
| 1998 | Beverly Hills, 90210 | Leanne |
| 1998 | Love Boat: The Next Wave | Layla |
| 2000–2002 | Dark Angel | Max Guevara / X5-452 |
| 2003 | MADtv | Jessica Simpson |
| 2004 | Entourage | Herself |
| 2005 | Trippin’ | Herself |
| 2009 | The Office | Sophie |
| 2010 | Project Runway | Herself (guest judge) |
| 2013 | Comedy Bang! Bang! | Herself |
| 2014 | The Spoils of Babylon | Dixie Mellonworth |
| 2015 | RuPaul’s Drag Race | Herself (guest judge) |
| 2017 | Planet of the Apps | Herself |
| 2018 | No Activity | Herself |
| 2019–2020 | L.A.’s Finest | Nancy McKenna |
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