| Year | Award | Category | Result |
| 2000 | Bambi Award | Shooting Star: Female | Won |
| 2000 | Satellite Awards | Best Supporting Actress in a Film | Nominated |
| 2000 | Screen Actors Guild Awards | Outstanding Motion Picture Cast | Nominated |
| 2002 | Golden Raspberry Awards | Worst Actress | Nominated |
| 2003 | Chicago Film Critics Association Awards | Best Actress | Won |
| 2003 | Dallas–Fort Worth Film Critics Association | Best Actress | Won |
| 2003 | Los Angeles Film Critics Association | Best Actress | 2nd place |
| 2003 | National Board of Review | Best Breakthrough Performance | Won |
| 2003 | National Society of Film Critics | Best Actress | Won |
| 2003 | New York Film Critics Circle Award | Best Actress | 3rd place |
| 2003 | New York Film Critics Online | Best Actress | Won |
| 2003 | Online Film Critics Society | Best Actress | Nominated |
| 2003 | San Francisco Film Critics Circle | Best Actress | Won |
| 2003 | Vancouver Film Critics Circle | Best Actress | Won |
| 2004 | Academy Awards | Best Actress | Won |
| 2004 | Berlin International Film Festival | Silver Bear for Best Actress[b] | Won |
| 2004 | Critics’ Choice Awards | Best Movie Actress | Won |
| 2004 | Film Independent Spirit Awards | Best Female Lead | Won |
| 2004 | Film Independent Spirit Awards | Best First Feature Film Production | Won |
| 2004 | Golden Globe Awards | Best Actress in a Motion Picture – Drama | Won |
| 2004 | Irish Film & Television Drama Academy | Best Film International Actress | Nominated |
| 2004 | London Film Critics’ Circle Awards | Actress of the Year | Nominated |
| 2004 | MTV Movie & TV Awards | Best Kiss of the Year in a Movie | Nominated |
| 2004 | MTV Movie & TV Awards | Best Performance of the Year in a Movie | Nominated |
| 2004 | Screen Actors Guild Awards | Outstanding Motion Picture Actress | Won |
| 2005 | BAFTA Awards | Best Film Actress in a Leading Role | Nominated |
| 2005 | Dallas–Fort Worth Film Critics Association | Best Actress | Nominated |
| 2005 | Emmy Awards | Outstanding Supporting Actress in a Limited Series or Television Movie | Nominated |
| 2005 | Golden Globe Awards | Best Supporting Actress – Series, Miniseries, or Motion Picture Made for Television | Nominated |
| 2005 | Hollywood Film Award | Best Actress of the Year | Won |
| 2005 | Spike Video Game Award | Best Performance by a Female | Won |
| 2005 | Screen Actors Guild Awards | Outstanding Miniseries or Motion Picture Made for Television Actress | Nominated |
| 2005 | Washington D.C. Area Film Critics Association Awards | Best Actress | Nominated |
| 2006 | Academy Awards | Best Actress | Nominated |
| 2006 | BAFTA Awards | Best Film Actress in a Leading Role | Nominated |
| 2006 | Critics’ Choice Awards | Best Movie Actress | Nominated |
| 2006 | Golden Globe Awards | Best Actress in a Motion Picture – Drama | Nominated |
| 2006 | Palm Springs International Film Festival | Desert Palm Achievement Award | Won |
| 2006 | Screen Actors Guild Awards | Outstanding Motion Picture Actress | Nominated |
| 2010 | International Online Film Critics’ Poll | Best Actress of the Decade | Won |
| 2010 | Saturn Awards | Best Film Lead Actress | Nominated |
| 2011 | Dallas–Fort Worth Film Critics Association | Best Actress | Nominated |
| 2011 | Detroit Film Critics Society Awards | Best Actress | Nominated |
| 2011 | Georgia Film Critics Association | Best Actress | Nominated |
| 2011 | Satellite Awards | Best Actress in a Film | Nominated |
| 2012 | Critics’ Choice Awards | Best Movie Actress | Nominated |
| 2012 | Golden Globe Awards | Best Actress in a Motion Picture – Musical or Comedy | Nominated |
| 2012 | Palm Springs International Film Festival | Chairman’s Vanguard Award | Won |
| 2012 | Teen Choice Awards | Choice Movie: Hissy Fit | Won |
| 2012 | Teen Choice Awards | Choice Movie: Villain | Nominated |
| 2012 | Teen Choice Awards | Choice Movie: Summer Actress | Nominated |
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